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A comprehensive MR analysis was performed on 139 eQTLs linked to anti-allergic drugs within discovery cohorts of 122,733 CAD patients, 68,157 HF patients, 395,795 MI patients, and 60,620 AF patients. Subsequently, these eQTLs were validated in replication cohorts including 42,096 CAD patients, 47,309 HF patients, 28,546 MI patients, and 55,853 AF patients. The analysis identified 51 eQTLs associated with anti-allergic drugs that are linked to CVDs. Specifically, 8 eQTLs were related to CAD, 34 to HF, 9 to AF, and 13 to MI. Enrichment…