How far have we come? From understanding collagen disorders to advancing treatment strategies

Collagen proteins play a vital role in numerous processes throughout the body, contributing to the function of various tissues. Consequently, pathogenic variants in genes encoding collagens are linked to a similarly diverse range of disorders, often with significant and severe effects.

Developments in gene editing now show promising avenues to tackle the root cause of these diseases in previously inconceivable ways. Kocsy et al., in their review [1], describe the diverse methods being…