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For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the differentiation process can lead to consequences, such as impaired tissue regeneration and the development of certain cancers.
In a new study published in Cell titled, “Design principles of cell-state-specific enhancers in hematopoiesis,” researchers from the Centre for Genomic Regulation (CGR) at Barcelona Institute of Science and…