Integrated single-cell atlas of human atherosclerotic plaques

Integration of public datasets into one atlas

We collected all publicly available single-cell datasets of plaque from carotid, coronary and femoral arteries covering a total of 259,493 cells (after quality control (QC)) of diverse cell types and pathologies (see Table 1). Fig. 1 shows the workflow to construct the single-cell plaque atlas. First, we pre-processed all datasets as described in the original publications. If no detailed description was available, we applied our own dataset-specific quality metrics (see “methods” section…