miRglmm – a generalized linear mixed model of isomiR-level counts

MicroRNAs (miRNAs) are small but powerful molecules that play a crucial role in regulating gene activity. These tiny strands of RNA are known to control how genes are turned on or off, and they’re involved in many important processes, from development to disease. Researchers often use RNA sequencing to understand how miRNAs behave in different conditions, such as in diseases like cancer. However, when analyzing this data, one of the biggest challenges has been how to handle the different forms of miRNAs known as isomiRs.

IsomiRs are…