Ultima’s ppmSeq Pushes Sequencing to New Levels of Accuracy

By Bio-IT World Staff  

August 28, 2025 | Ultima Genomics unveiled updates on the single-nucleotide variant (SNV) detection capabilities of its plus-minus sequencing (ppmSeq) technology, which were published at bioRxiv (DOI: 10.1101/2025.08.11.669689). The updates elaborate beyond the limits of currently available minimal residual disease assays. 

According to the authors of the paper, state-of-the-art molecular de-noising approaches for DNA sequencing rely on duplex sequencing, where both strands of a single DNA molecule are sequenced to…