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Scientists at the University of Antwerp and KU Leuven have shown that blocking ferroptosis, a specific form of cell death, can better protect donor organs during transplantation. ‘We developed FXT-001, a small molecule that protects organs against ischemia–reperfusion injury, one of the main causes of early transplant failure,’ says Professor Tom Vanden Berghe, head of the Cell Death Signaling lab at UAntwerp. Spin-off FiriX Therapeutics is now advancing ferroptosis inhibitors toward the clinic.
Organ transplantation saves…