RNA sequencing reveals early mitochondrial dysfunction shared across ALS mutations

Using the gene scissors CRISPR and stem cells, researchers at Stockholm University and the UK Dementia Research Institute (UK DRI) at King’s College London have managed to identify a common denominator for different gene mutations that all cause the neurological disease ALS.

Early signs in the mitochondria

The research, recently published in the scientific journal Nature Communications, shows that ALS-linked dysfunction occurs in the energy factories of nerve cells, the mitochondria, before the cells show other signs of disease, which…